Molecules are lifeless, yet appropriate assembly of molecules (although it is very complex) can compose life. Now the molecules which are responsible for the functioning of life are commonly known as biomolecules (e.g. lipids, carbohydrates, proteins, nucleic acids etc.). The physical and chemical behaviour of all the biomolecules (mainly composed of C, H, N and O and tiny amount of trace metals) along with their differential presence throughout evolutionary processes across various life forms are responsible for this spectacular diversity, intensity and complexity of biology.
Towards this infinite horizon, we will try to keep little footsteps by understanding the chemistry of those biomolecules and how their selective and specific interactions among themselves as well as with their surroundings impose dynamicity to the whole ensemble. (see next section for details)
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Group News:
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December 2023: Ekta and Arshdeep's work (protein's conformation modulation in crowded media by pH-modulatory enzymatic reaction) is now out in J. Phys. Chem. B.
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November 2023: Congrats to Priyanka for J. Mater. Chem. B. It is a beautiful study illustrating sequence-specific control over oligonucleotide digestion (that also includes thermodynamic insights) with a biosupramolecular complex.
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September 2023: Rishi's work is out in Chemistry - An Asian Journal. It will be featured in Early Career Researcher Special Collection. #ACES talent
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April 2023: Congrats Aastha and Priyanka for ChemComm.
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February 2023: Many congratulations to Ekta for her ACS NANO paper !!​
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October 2022: Congrats Akshi and Shikha for ChemComm. Here we showed chemotaxis of alklaine phosphatase in gradient of metal ions and carbohydrates.
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July 2022: Our article showing chemotactic property of DNA in gradient of metal ions will be featured in ChemComm 2022 Emerging Investigator collection. Congrats to Shikha, Ekta and Priyanka !!
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June 2022: A beautiful work showing spatiotemporal pH modulation in gel system by Rishi, Priyanka and Ekta published in Chemical Science. Another well-performed work by Rishi, Ekta and Shikha with G-quadruplex activity and its impact in spatial localization published in ChemBioChem. ChemBioChem article has been selected as Front cover and also as VIP article.
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February 2022: Two new articles just published. Congrats Priyanka and Surinder for ChemNanoMat and Akshi and Suraj for Chem Commun (here they depict micropumping from blood plasma due to acetylcholine esterase activity).
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November 2021: New article out in Chemical Science. Great work by Priyanka, Ekta, Surinder and Rishi. Here we have explored a reaction-diffusion phenomenon of self-assembled structures in enzymatically generated agonistic and antagonistic condition.
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June 2021: Rishi's work just out in ACS Catalysis. Congrats to Rishi, Ekta and Basundhara. This work shows an exciting pH switchable catalytic behaviour on nanoparticle surface by modulation of multivalent interaction with nucleotides like AMP, ADP and ATP.
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June 2021: Latest article just out in Langmuir. Congrats to Akshi. This work elucidates aspects of membrane-bound enzymes in crowded media in terms of both catalytic behavior and inhibitory actions.
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April 2021: New article out in Chemistry - A European Journal. Congrats to Ekta and Basundhara. Here we have shown self-powered catalytically driven assembly of catalytic unit results in unconventional cascading property.
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November 2020: Congrats Sheetal and Basundhara. Masters students' work from our lab just out in ChemBioChem. We have shown the charisma of a pre-historic protein cytochrome c. It has promiscuous proton transfer ability but only in self-organized media where acid-base and redox pathway both can operate depending on the pH of the media. This work has just been selected as Cover Feature of the April 2021 issue of the journal !!
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October 2020: In latest Chem Comm, how to regulate onset of fluorescence signal in a supramolecular system has been shown. Thanks to Leonard Prins group !
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August 2020: New article out in Angewandte Chemie !! Thanks to Leonard Prins group at University of Padova, Italy. Here, nucleotide selectivity in designing transient nanoreactor in complex chemical network has been demonstrated.
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July 2020: Congratulation Akshi for your CHEMCOMM ! Formation of thermo-stiffening microemulsion-based-gel, showing nanoconfinement effect of carbohydrates as efficient batch bioreactor for entrapped enzymes (even thermophilic ones) has been reported.
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September 2019: Congrats Ekta for your first publication @ChemSystemsChem. Here we have shown via kinetic simulation that in a multivalent fuel driven multistep assembly process, composition of transiently formed intermediate species changes in a non-linear manner and is a function of strength of dissipation.​​​
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